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KMID : 1007520200290091251
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Food Science and Biotechnology
2020 Volume.29 No. 9 p.1251 ~ p.1260
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In vivo the antioxidative extract of Averrhoa carambola Linn. leaves induced apoptosis in Ehrilch ascites carcinoma by modulating p53 expression
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Siddika Ayesha
Zahan Tasnim
Khatun Lipy
Habib Md. Rowshanul
Aziz Md. Abdul
Tareq A. R. M.
Rahman Md. Habibur
Karim Md. Rezaul
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Abstract
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This study was designed to evaluate the antioxidant activity of methanol extract of Averrhoa carambolla Linn. leaves (MELA) using DPPH· and ABTS·+ free radical scavenging assays whereas its antineoplastic effect against Ehrlich ascites carcinoma (EAC) was assed using viable cell count, life span, body weight gain and hematological parameters of experimental mice. Results showed that rich phenolic and flavonoid content of MELA had moderate dose dependent free radical scavenging activity (IC50: 62.0 μg/mL for DPPH· and 6.0 μg/mL for ABTS·+). In vivo antineoplastic assay, MELA significantly (P?
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KEYWORD
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Averrhoa carambolla, Leaves, Antioxidant, Antineoplastic, Apoptosis
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